I set up my saddles so they're comfortable, and they feel just as comfortable in any terrain. I tilt them down about .5 cm. over their length. Works for me both sitting up on the tops and all the way down, forearms horizontal. Of course different parts of my anatomy are getting the pressure as I rotate my pelvis, but saddles seem to be designed with that in mind. I've been using Selle Italia saddles for a long time. A 10% grade is only 5.7°, hardly noticeable compared to our normal change in pelvic rotation in the various positions on the flat.
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