Originally Posted by
MoAlpha
It's not just what, but how much people eat. Most of what we know comes from industrial societies where almost everyone is in positive energy balance. This factor is a huge risk in itself and it undoubtedly determines with how people metabolize macronutrients to a large extent. I suspect, for instance, that sugars aren't nearly as toxic in people who aren't in energy overload.
I don't know exactly what you mean by energy overload. It is also possible that sugars aren't harmful unless they are habitually consumed, sort of like how a couple alcoholic drinks a week probably won't damage your liver but drinking all day every day will.