I use Brook pro on my training rides, and Fizik aliante for races and brevets (different bikes).
I do get some annoyance with either saddle even though I try to stand frequently, but the more klm I accumulate the less annoying it becomes.
Also, I find that riding uphill put less pressure on the saddle so on rides with a lot of climbing you can also relieve the pressure on the downhill.
On long Brevets I do not load my rear pockets, but use a handlebar bag so there is less pressure on the saddle.
On a 6X200 brevet several years ago I developed a saddle sore towards the end, and a few years later on a similar 6X200 I made it my business to stand a lot.
I avoided the saddle sore, but developed numb hands that was worst.