My wife and I only had minor soreness and a small welt after the first one-got over it in a week or two. About due for the second one-hoping our pharm. has it in stock-they said they would hold one for her, I didn't ask to have one held (maybe should have). I've met people who have had shingles (all had gotten over it, though some had a tough time with it. Sure isn't something I want to experience!