Originally Posted by berner

Is there a possibility the problem might derive from the bike shorts themselves and have nothing to do with bike fit or saddle? I bring this up because, in the past I've had two bike shorts that did not work for some reason. One pair caused chafing severe enough I was carrying extra chamois cream in a tiny plastic bag. The other shorts caused a rash at the sewn on band just above the knee. I'm allergic to latex so I surmise latex in this area caused the rash. Since fabrics may come from anywhere on the planet so it could also be that the it was not latex at all but some unknown substance used by the manufacturer. I have in mind here the situation of a number of years ago when it was discovered that Chinese supplied baby formula contained melamine. I eventually had to throw both those shorts out.

The other possibility is the saddle. For myself, I need a saddle with a very narrow horn area, the part that juts out in front of where the sit bones rest. So narrow, in fact that I have to customize saddles by narrowing that area myself with a heat gun. Until I discovered what I need in a saddle, I was contemplating giving up cycling.