I am a guitarist at times I made my living at it and now repair guitars for a living. Generally the bike has not bothered my hands but if I keep them in one spot and a lot of weight on them it can cause some issues immediately after riding. I can tell you that carpel tunnel is not an issue and most who get it have a pre-disposition to getting carpel tunnel. Others can abuse their hands and never have problems, that has been reported by many surgeons. Bottom line is watch and be careful I love playing the guitar and have some fine guitars but I also enjoy riding a bike, do not want to give that up. I am runner too and you might try that too.