I'm running 49 x 20 which is about 68 gear inches. A ratio of 2.45:1
38 x 16 is around 66 gear inches. A ratio of 2.38:1 They're as near as makes no odds identical: about 3% different.
This ratio gets me up most hills in my area, without spinning out dangerously on the descents, and lets me cruise steadily in most conditions. I ride on and off road.
Back in the day when I took it more seriously and rode 7 days a week, I had a theory that the best gear ratio in inches, for a moderately fit rider, is roughly equivalent to the rider's height. I didn't deliberately apply this rule when setting up my bike, but I ended up with a 68 inch gear and I'm 67 inches tall. Coincidence?
EDIT I've just measured my wheel with the current tyre on it. Nearer to 27 inches than the 28 I used in my initial calculation, so my gear is nearer to 66 inches.