Last year I moved from a place where my riding was relatively flat, to a place where it's hard to go 5 miles without 1000' of climbing. (At both ends of my road are 16-20% grades that have to be dealt with before you can even begin to start riding the other more gentle climbs.) I "everested" in 300 miles last summer! I learned I'm a terrible climber, and 58 year-old knees don't like grinding.
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The first thing I did was put an 11-40 on the rear with a wolfstooth. That was better, but wasn't enough with the compact in the front. So I also switch out to the Absoluteblack subcompacts 46/30. Better, yes, but I still find myself doing 4mph up those grades at the end of my road.