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tobukog absolutely. Bike sizing is something that gets no thought often, although I heard in an interview with Dion Beukeboom (on thetrackstand podcast) that they had tested different size GIANT bikes and sized down an unusual amount for his upcoming hour attempt because it turned out much faster (if you could get the reach from a smaller size, maybe aero pedestals under the pads > aero headtube) interesting stuff. In theory you also move the rider farther away from the top tube doing that though, which can be bad....maybe
John Cobb told me the first time I went that I'd spend an hour or two in there, come out thinking I'd figured something out, and then a day or two later realize all I had left with was more questions. So far, that's been spot on.