Take a look at Selle Anatomica and/or Rivet. Both are (most models) leather saddles with cutouts, designed by people who've done lots of double-centuries and other ultra-endurance rides. I use a Selle Anatomica Titanico: it's not perfect, but it's way better than all the other saddles I've had.
If cost is no object, you might want to investigate Specialized's new 3D-printed S-Works Power with Mirror saddle, "only" $450. Or the (also 3D-printed) Fizik Antares Evo Adaptive line, starting at $250.
Last edited by dorkypants; 08-16-20 at 09:58 AM.