Originally Posted by
Barrettscv
The chainline on the RX-600-11 is optimized for modern disc brake bikes with 142mm thru-axles. It's possible that this crankset will have chainline related cross-chaining issues if installed on a rim brake bike. The big-big combination would be problematic.
I have a White Industries crank with a wider chain-line along with a 135mm hub in the rear. Works fine, even on big-big (and my rear big is 36T on one wheelset, 34 on the other). My bet is it most likely will work.
Anyway, the point was that it is another option (and that this is now main-stream enough to be an option with Shimano, FSA, etc.), not that it will work with any setup.