I toured with a guy who used a road bike and bikepacking bags. Full frame bag and handlebar bag/cradle and he said he was set for a full day of riding between food stops. Had a ultralight tent, clothes, water/etc. Looked like a slick set-up as a larger saddlebag could be added too. Seemed like it worked great and he was happy, but very $$$.
These two were what he used:
https://salsacycles.com/components/c...thing_cp_db_fp
https://salsacycles.com/components/c..._ht_framepacks