I have a pacer with campy ergos plus ultegra long/regular-reach brakes. The dual brake release in this combo makes it easy to remove wheels with big tires. I'm currently using 32's. I started with 25's, but the bike was too stiff. I'm much happier with 32's. Much better ride over imperfect pavement, and I'm not any slower according to my Garmin. Then I changed the steel fork, which I never liked, to carbon IRD Mosaic 57, and the bike is even more plush right now. I can put power down over very rough patches, where I had to lift off the saddle and coast on the 25's. The price to pay for all this comfort is in out-of-the-saddle high-power attacks, where the bike just does not feel as solid as it did with the 25's and the stiff fork. It's mostly due to front-end flex. But it feels so good after 100 miles...