Back in the early 80s, one of my co-workers at Trek built himself a 12# lugged steel road bike, using all the fancy-pants weight-weenie components of the era: Zeus 2000 cranks and freewheel, Regina titanium chain, Huret Jubilee derailleurs, CLB Professional brakes, Hi-E hubs and rims, Clement track tubulars, etc. The frame was Columbus KL. He was a machinist and did things like drilling out the dropouts and milling flutes into the steer tube.
Whatever turns your crank.