I want to revisit this because I was having knee trouble on my Rambler and I found a solution. I often have some knee pain for a few weeks when I start cycling again after a layoff, but this went on and on. I finally figured out that if I point my toes rather than letting my ankles drop, it really helps. This seems like it has most to do with how the weight of the leg is supported. I don't know if seat angle would have made a difference... Maybe.
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Genesis 49:16-17