Something like tubes vs tubeless would be an issue with the person's overall mobility.
Imagine what it is like to fix a flat on a bicycle. Then for the wheel chair, hop out of the seat, and work on one's wheelchair tire, then hop back in.
Tannus makes reasonably good quality solid rubber bicycle tires. I don't know about wheelchair specific sizes, but perhaps they would be similar. A pain to mount, but they last a good long time once mounted.
Of course, racers likely worry about small efficiency differences, just like many cyclists.