When I test drove my Domane, for some unknown reason the tires were pumped up to what I can only assume was maximum pressure. The bike felt terrible and riding a few blocks, I lowered the pressure. Rode the bike ten minutes longer and lowered it again. Now the bike finally felt good and I eventually bought it but it always bothered me why a Trek Store would pump up the tires so high for an endurance bike.
After riding the bike for one day the stock tires had to go and they were replaced with Rene Herse tires and it transformed the bike.
There is some excellent advice so far in this thread which is nice to see. I hope you find something that works for you.