Originally Posted by
genejockey
Can't help you there. My place in the whole pipeline is standing at the top tossing things into it. I'm not a doctor and don't play one on TV.
What I'm getting at is are two drugs such as Humira and Enbrel sufficiently different that the immune system responds to the second as if it had never seen an anti-TNF drug before? Or do the anti-bodies that someone develops for the first drug, which linger in the immune system memory, make it easier for someone to develop anti-bodies for the second?