Originally Posted by
Velo Vol
What I'm getting at is are two drugs such as Humira and Enbrel sufficiently different that the immune system responds to the second as if it had never seen an anti-TNF drug before? Or do the anti-bodies that someone develops for the first drug, which linger in the immune system memory, make it easier for someone to develop anti-bodies for the second?
The part of Humira and the part of Enbrel that bind to TNF are COMPLETELY DIFFERENT. So, not likely that antibodies against one will crossreact with the other. Is your loss of effect from these because of anti-drug antibodies?
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