I looked at the
TRP website and it recommends that Spyre brakes should use a 160 rotor in the front which is an odd size for a road bike. Really there is no harm in upgrading if they just don't work for you. Before I would upgrade I would make sure the setup is correct, that I had the best housing available and that the pads etc are free from crud, oil and other contaminants.
As for the upgrade path, I remember someone on here, that had huge problems getting these to work. Again the TRP website says to contact them to ensure that your lever and upgraded brakes will work well together. Good luck.