Aero wheels and aero frameset won't make a very big difference. They are among the lowest bang for the buck improvements you can make. Even though they look really cool, I think they should be the last things that you buy.
If you want to make a huge difference, focus on your positioning and the aerodynamics of your body. A set of aero bars that you can live with -- and that get you into a good position -- are probably the biggest single improvement you can make. Improved body position, compared to the drops, can gain you 1 1/2 to 2 mph. That's huge. Very close behind them would be an aero helmet and well-fitting skinsuit. For less than the price of a set of wheels, you can go with the bars, helmet, and skinsuit and end up with many times the improvement that the wheels would have provided.