Question 1 - indoors only I assume? If you're going to be outdoors at all then the disc doesn't really make sense.
Question 2 - stiffness. A 5 spoke is going to be stiffer than basically anything else. Something to think about
5 spokes generally aren't all that aerodynamic (relatively to 3 spokes or deep section "normal" rims) and have such a presence mainly because a.) stiff and b.) the iO looks cool and they gave them to basically everyone who'd ride them for ~20 years.
Everything you've mentioned will be sufficiently fast. In my own tunnel testing, the difference between an 80mm wheel, trispoke, disc and 5 spoke was a handful of watts. (5 from best to worst) the 5 spoke was the worst.
Tyre to rim profile matching is probably going to be more important than the wheel itself.
Just my thoughts though