I thought the weight would be a big disappointment on my Pinarello (17 lbs), which I consider an aero bike for the most part. But the gains I get from the stiffness offset the weight. I don't feel like I lose anything in climbs. I like the stiffer frame. I prefer slightly shallower rims, though. I like my Enve 3.4 for all-around duties. That Scott looks really sweet! The Pinarello is obviously fully internal but is also very expensive.
I've always been very partial to Specialized products and would probably look at the Venge if I were in your shoes.