Originally Posted by Riveting

+1 for tubeless, and always carry a tube and some sort of tire boot, just in case you get a small tear that slime can't fix. I've had a dozen goatheads (at once) in my 29er 2.3" tubeless with no noticeable pressure loss, I just left them in until I got home. If you prefer to pull the goatheads out while on the trail, make sure to first rotate the goathead to the bottom, and wait ~20 seconds for the slime to pool at the bottom of the tire before pulling it out, waiting longer may be necessary if the slime is older and dried out, and therefore more viscous. I'm still on the fence with going tubeless on high psi road tires.