When I went for my professional bike fitting, one of the things they did was to measure my sit bones. (Okay, I admit, that seemed a little weird to me at first, too.) Swapped out the existing saddle with one 10mm wider, got it adjusted, and it's like sitting in an easy chair compared to the original.
I really believe that all the adjustments fore and aft, height, and tilt, won't really matter much if it feels like you're sitting on a fencepost.