About 2 years ago I had a bike spill and hurt my sciatic nerve. Since then, I've been sensitive to saddles (a bony behind doesn't help) and some have aggravated the nerve. I tried a huge number of saddles from Brooks, Selle Anatomica, WTB, Specialized and Bontrager, etc. The better ones were Fabric and Giant, but both weren't great. My favorite saddle is the SQ Labs saddle that I've ridden on for months. It's very sensitive to adjustments, but when you nail it, the saddle is incredibly comfortable and has never irritated my sciatic.