I assume you mean new wheels for the Domane?
I bought a Fuji Sportif (Al frame endurance geometry) a while back and it was comfortable but really sluggish. I threw some Vuelta rims and Conti Sport II tires on the thing, and it felt almost reasonable ... not riding through tar any more.
I bought some cheap Chinese CF rims and some Hutchinson Fusion 5s (I think) and now the bike is downright sprightly.
I can guarantee that your mileage will vary .... but I know that for me, there was a distinct step up in responsiveness with each improvement in wheels and tires.