I agree that 1) it all depends on how much you're going to carry, and 2) a trailer will likely increase the amount you carry.
If you're going to be touring urban areas, a trailer could present parking problems. Some businesses and lodges will let you bring a bike inside (always ask first), but that gets way more difficult with a trailer. Ditto if you ever encounter obstacles like stiles in trails, or fords, or even hotel stairs, where carrying the bike is required.
I toured over 2000 miles one summer on a road bike, and it kind of beat me up. And I was young then. The heavier touring bike I replaced it with was more comfortable.
Over the last decade, I greatly reduced my pack weight (under 20 lbs) and found I no longer needed a triple crankset. My new bike has a low ratio of 29 g.i. and I like it.