I think your saddles are a good choice but you know best since you have experienced them. I use the B-17 on my touring bike.
My point however is the position of your body. I think others have commented about this. And, I note in your picture you do not have fenders. Not required but they are preferable.
Having said all this, when I started touring it was credit card with a handlebar bag on my Trek 2120. The tour was typically 7 days not more than 10. I would go around 80 miles, sometimes more or less. My position on the 2120 bike is a little more straight up than my Domane. So, depending on the length of the tour, daily miles and time of year, I expect the Domane could work. And as others have said, take a few day test tour or even one long one. You'll succeed either way and perhaps sacrifice some comfort. But, you will have answered your question.