Glad to hear so many positive responses about this bike, I can't wait to start the building process. My last bike had Ultegra di2 so that's the plan for this one along with an Ultegra crank and cassette. Not sure about wheels yet? My previous bike had some Easton EC90sl's that were 35mm deep, 28mm wide (19mm inside), light @ 1,500g, and felt really good so something along those lines would be great.
I'm also hoping the 600series carbon rides as well as the 500series. I'm sure it will but I only rode Domane's with the lower grade frame material. I could have bought the sl instead of the slr but the slr was 50% off so the price was within a few hundred dollars so I went for it.
Anyway, thanks again for the responses and let's see some of those Domane's. Post some pics to give me some motivation please!