You're going to lose some lateral stability especially in the turns. However, they build radial wheels without any crossing of spokes. Lacing of wheels is dependent upon the weight of the rider, the type of riding - rough roads, turns, quick starts, power, and how long do you want your rims to last. Once a rim gets a distortion, it's permanent, then you have to adjust the spoke tension to get the wheel straight, the spoke tension will then be uneven.