Hybrids are more comfortable for people with terrible flexibility, and the fatter tire handles a riding style that just plows into stuff on the road while sitted weighted on the seat.
Endurance road bikes can be more comfortable for people with decent flexibility because it better distributes your weight between the front and rear tire so their is just less weight on your rear end, the hoods on curly bars actually are a better hand position for not pinching anything over longer rides, and they can handle anything you run into on a normal road as long as you can slightly unweight yourself and watch where you're steering the bike.
Of course the big thing is that endurance road bikes are faster and less fatiguing to ride over the same distance, because of smaller tires, a more aerodynamic position, and less weight (minor factor).