I did two of the same centuries with two different tires a week apart. A route of about 50% gravel/trail and 50% paved. Hutchinson Overide 38 and new too me WTB Riddler 45. Both have pros and cons and the times/effort between them was dictated by the wind direction, not the difference in tires. I did the C&O/GAP last year with the Override. This year will be with the Riddler. I have multiple wheels sets and swap around because it is easy to do so I don't have to pick just one tire. My "gravel" bike is also a fire road bike, road bike, and a touring bike. More often than not in the same ride. There are people that do the same with a 28 or 32 and are perfectly happy. I have no idea how but....