I generally don't stop for stop signs here in our small town, but the traffic level is low. Especially if I'm out riding at 5 AM. But... I constantly look out for traffic both directions several times before proceeding through.
That being said, if I'm riding in an unfamiliar area, I tend to stop at stop signs. At home, I know which streets are going to be the busy streets. When I'm out elsewhere, I won't know how likely there is to be cross traffic.