I used a B.O.B. for one bike tour. It worked great, but I preferred panniers and gave the B.O.B. away. I don't have one bad thing to say about the trailer, just personal preference.
BTW...when I toured with my little sister many years ago, we used panniers. I just packed her up with the light, fluffy gear and I carried the heavy stuff. We biked from New Orleans, LA to just past Memphis, TN. As she got stronger I added a little weight to her load.