Because of asthma and chronic sinus infections, I've been off and on Pred many times for extended periods. Yeah, it Did make me feel great pretty quickly. But as mentioned, I did gain weight, and it caused a noticeable change in temper. One time I got so mad, I broke an antique wooden chair of my wife's into little pieces with my hands. She prefers that I don't take it any more. I try not to.