I for one, find more padding works better for me, and gel padding at that. I think the most comfortable saddle I have is the Serfas Dual Density DDM-CT with cut out. I don't like the friction caused by the Lycra cover, though. They also offer the TRS-2 Terazzo, which is a mountain bike saddle. It's similar in comfort to the Dual Density but with a cover with far less friction.
I'm currently trying to get used to a Specialized Canopy, which isn't bad.
In my experience, it takes a good 100-200 miles to figure out if a saddle is going to work.
-Matt