I have struggled with saddle sores as well. Last year I went to a fitter and among the adjustments he turned my saddle 6 degrees to the right. It has never been more comfortable and I do get less chafing. I do not even think about my saddle or seat position anymore and I used to always be fidgeting with it... I do not notice the off center nature of the seat. The only difference is now the boys always go left when before they took turns going left then right.