Madone came in two Geos pending the yr. H1 and H2. Lower tier grades say $3500 and below were all H2 geos, lightly slacker, taller head tubes, putting the body more upright and easier to stack 30mm of spacer under the stem to make it feel less racey. H1 geo is pure tour de france fit, short head tube, more aggressive geo, larger seat to handlebar drop. Most Cannondale EVO/CAAD10/12 will be along the lines of the H1 geo.
the Domane is even more relaxed version of the H2 geo, with even a taller head tube but most important, it can fit larger tires then a 25c. People are running 28-30c tires easy in the Domane, Cannondale version of this bike is their synapse. For Giant bikes, it would be their Defy models.
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if you're more flexable and/or have longer arms, you can get away with the aggressive frame style
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