I am currently running a 48 tooth 1x 11 up front on a crux.
I am used to running 50+ up front on a single speed track bike so it is a bit of a change and took a bit of getting used.
The acceleration and top speed are noticeably different at full sprint. I know re-gearing it makes a huge difference. when I originally got it, it came with a 43 tooth up front. For a bit I would spin out on that. So I had to bump up to the 48, I am considering the 50 now.
Also putting 700x20 vs the current x32's on my crux made a difference. But the road conditions are so bad here I went right back to the 32's. I can't take corners hard on the 32' because they will slide from underneath me which is not a nice feeling when you are used to being able to take turns at top speed and being confident in your bike. I haven't had a chance to try big slicks yet. They may make change my mind.