I was 335 when I started and I ride a Trek 1500. The first 1200 miles on the factory 24 spoke wheels. I recently bought a set of 32H Open Pro's with Mavic rims because I have been straying further from home. I've always ridden bikes though so even though rusty I had the skills available. The only other change I made was to the saddle, the stock saddle was very uncomfortable. I went with a mountain bike saddle with heavy duty rails. For a saddle the width of you seat bones are more important than the width of the flesh !
Shog