Just to be more clear, your revised question is too vague. I have learned a lot of things that probably wouldn't make sense to you at your level of experience. So what specifically is keeping you from starting to build a frame? Are you planning on building fixturing first?
Although, the one thing that I have learned is that you should plan on cutting up and throwing the first one away. Boeing did it with the first 717, and that's millions of $ going to scrap.