Originally Posted by
Retro Grouch
You say you have a new hanger but you didn't say if it has been aligned with a gauge.
9-speed cassettes and above are real sensitive to precise hanger alignment and one of the ways bad alignment manifests itself is the issue you have described for us.
The OP has a 10 speed cassette. Tiagra 4600 and 4700 are both 10 speed and incompatible with each other