You will probably get a variety of opinions here, but so long as it's not effecting the beading on the rim and isn't in the tread wear area of the tire, I wouldn't hesitate to run it. I might put a piece of patching on the inside of the tire while it was off to protect the tube and keep it from coming through the sidewall. I had a tire do that to me once. Even then it last quite a while because it wasn't running against anything. Good luck.