Super D, the real bang for the buck in terms of things that definitely make one faster are:
- Skinsuit
- Bike fit with focus on aerodynamics
- Helmet
- Shoe booties
- (certain) Aero Front wheel (Zipp 808 seems to be the best verified bang for the buck)
4 of those 5 relate to one's body. The body composes 90% of the things that make drag. The aero front wheel is most of that remaining 10%.
The frame is mostly just the platform on which everything is attached. It must be stable. A frame being aero is only a small bonus when compared to the entire package.