Originally Posted by Bryan C.

I went with a GRX Di2 2x set up with the 817 1x specific rear derailleur and the 815 front derailleur. 48/32 chainrings with an 11-42 shimano cassette is actually a nice set up. Plenty of climbing ability and more than enough on the top end for me. It shifts perfectly too.

There are certainly many other cheaper and easier options out there. And I'll echo the comment that there really is no wrong way to get the gearing. Just some set ups work better for different people and their riding conditions.