Velo Vol 

Sounds like witch doctor drugs. #Quack

Velo Vol 

Doing any snow shoveling today? DougRNS

abshipp 

Ah, lucky for you. There is zero maintenance on my local path in the winter.

Thankfully we don't get a huge amount of snow here, so the roads pretty much stay clear. Even if they aren't, traffic is close to nonexistent on my usual routes.

phrantic09

I take a drug designed as an anti-convulsant as a mood stabilizer, I don’t know if they understand how it works, but it does.

genejockey 

Back in the 80s, I was part of a team that worked on an approach similar to Enbrel, but against HIV (receptor fused to antibody Fc fragment to increase serum half-life). When we moved forward into clinical trials, many AIDS experts told us, with absolute certainty, and great specificity, exactly why it wouldn't work .

It turned out that it actually didn't work. But NOT ONE of the experts was even close to being right about why. The human body, and disease is WAY, WAY more complex than any system we can devise to test drugs. That's why we do clinical trials.

Indeed, TNF was originally expected to be a drug against cancer, because In Vitro it killed tumor cells while leaving normal cells intact. It wasn't till they did toxicology in mice that they discovered the systemic effects it has. That discovery is what led to the idea of blocking it as a treatment for autoimmune and inflammatory disease.

WhyFi

Already done. Had to scrape the icy, slushy stuff with flat spade shovel first.

WhyFi

The paths get used quite a lot, even in the winter. There would be a lot of pissed off Karens if walks around the lake or along the rivers were taken away.

DougRNS

Negatory, see post #2127

genejockey 

When I was a wee lad, we moved to a house on a lot maybe 100 feet wide, so we had 100 feet of sidewalk to shovel when it snowed. Dad insisted that it be shoveled the full width of the walk, not just a shovel's width path. Then there was the driveway, and the turnaround, and the walk from the garage to the house. I'm the youngest of 6 kids, so there was always someone to shovel snow, till I went off to college.

THEN, and only then, Dad got a snow blower.

WhyFi

I rolled my eyes when I was younger and my dad complained about houses on the corner - typical old man grousing.

Now I have a house on a corner with a ~200' sidewalk on the side in addition to the ~100' in front. Yeah, we got a snow blower after our first winter in the house. Truth be told, it's not *that* bad but for the fact that the 200' side regularly gets covered by the heavy, wet stuff coming off of the blades of the snowplows as they roar past. Even the gas, two-stage snow blower isn't happy with that.

datlas 

Good ride today. We did get buzzed by a passing light truck, which made me yell at the top of my lungs, FOUR FEET, *******! The French shower had plenty of room but came damn near close to hitting us.

Other than that, it was a fantastic fun fall ride.

What starts with “f” and means ride?

Velo Vol 

The question wasn't directed at you.

WhyFi

You never let that stop you.

BillyD

Smart man, amiright? What's the sense of having kids if you don't put them to work? They're eating up all the food, aren't they?

#buildscharacter

BillyD

Tell you the truth, as a driver I wouldn't even know about the 3 or 4 foot law if it wasn't for this forum. I mean, I haven't taken a driving test or read the manual since 1960-something.

Velo Vol 

There are children on this website.

genejockey 

That was, I believe, the gist of his thinking. Unlike my Mom, who was a doctor's daughter, he'd grown up without servants*, during the Depression, so the idea of hiring strangers to do what he could make us do was foreign to him.

*Mom used to say, "I grew up with a cook and a housemaid, but your father said, 'Let me take you away from all of this!'"

Velo Vol 

No one could possibly be wondering if Bad Doug shoveled today. I tagged him so he can vicariously experience his snow shoveling fantasy.

abshipp 

Who approved them?

Unless expressly permitted by supplemental terms, our sites and services are intended for general audiences 18 years of age and older, and access or use by anyone younger is not authorized.

LesterOfPuppets

Fling

Bah Humbug

I went through driver’s ed in 2000. It wasn’t covered then either. And it’s not like they ever make you take a refresher.

Velo Vol 

Is this optimal pacing?

seedsbelize 

Black spokes? I don't generally like them, but they could be the only option, unless I stick with the used ones.

In Covid news, an acquaintance of the wife went to the hospital yesterday. An obese diabetic woman in her sixties. She is regularly observed at buffets, eating like she doesn't have diabetes. We are all telling ourselves there is reason to hope.
#Sad

MoAlpha

Big W/kg!

WhyFi

This made me do a search for the men's record, out of curiosity, and I came across this. I haven't watched this whole video, but the first few seconds are just mind-blowing to me.