genejockey 

You should assume this is happening as we speak. But it's not just thousands of people with RA that you need. You need thousands of controls without it. Even then, needle in a needle stack.

MoAlpha

That's been done over and over, I assume. What one comes up with in such an effort is a bunch of genetic variations with varying degrees of statistical association with the disease. I don't know the RA genetics literature, but I assume some of these associations have yielded important mechanistic insights into the causation of the disease and provided leads for novel treatments, the most promising of which are in various stages of investigation or development. There are no silver bullets for so-called polygenic diseases.

genejockey 

And then there's the question of gene expression, which can't be answered by sequencing the genome, and epigenetics, which ALSO can't be answered by sequencing the genome.

LesterOfPuppets

A-ha, correct you are.

ls01

if you can, just pour a small amount of gasoline directly into the carb. Then start as if everything is normal. It should fire up, run a second or 2 and die, If its a fuel issue.
If it won't start at all its likely an ignition issue.
Best case, when you prime it with fuel in the carb it will self prime after that and continue to run normally.

Edit; originally posted to the wrong member by mistake.

datlas 

I love it when you guys talk science!

LesterOfPuppets

The US ranks 43rd in percentage of COVID cases sequenced. Sad.

https://www.washingtonpost.com/world...heck-variants/

Interestingly enough, I think we're still ranked 43rd for infant mortality rate also.

Velo Vol 

Am I going to have to figure this out, once I get my handlebars wrapped?
Correct.
Nope. Every once in a while a new drug gets released, which maybe offers marginal benefit for 20% of patients over existing ones. Until that drug stops working for them, too. Rinse, repeat.
You're welcome.

genejockey 

I cannot tell you how embarrassing it is to be in Biotech in the US, which SHOULD BE the best in the world, and to have lagged SO BADLY in testing, and now to learn we're so far behind in viral genome sequencing as well.

genejockey 

Knock yourself out.

genejockey 

Based on what I've been learning the last year or so, the promise of individualized medicine is just that at the moment - a promise. You need to look at large sample sets, because responses are so variable, and you need to be looking in the right place. If you sample set is too small, you can get misled by apparent correlations that don't pan out in larger datasets, and if you're not looking in the right place, you won't see where the real correlates of response are.

ls01

Dads out if surgery and in his room recovering. They were able to open up 2 of 3 stents. Thats all the info I could get from Mom. Good enough for now. Thanks for the prayers and positive vibes everyone.

BillyD

Brutal.

Did you stock up on essentials before the storm?

genejockey 

I can give you a good deal on paper towels that don't fit a standard paper towel holder.

MoAlpha

We're also not nearly as good as we should be in terms of aggregate clinical outcomes. We get what our system is designed to provide.

BillyD

Every 3 hours I was out there yesterday to keep up with the storm, using an electric snowblower which I can push back up the hill. It works well on 2 - 5 inches of snow. Exhausted today, though.

BillyD

Vol might need it, he's prolly socked in.

genejockey 

If he can't get out to get them, I don't imagine UPS can get in to get them to him.

big john

Hard to imagine anyone getting out with 3/4 inch of snow.

genejockey 

You laugh, but picture the bloodbath on LA or SF freeways with 3/4 of an inch of snow.

kissTheApex

Great news! Hope he continues to do better!
Or our nation’s capitol capital for that matter. My saving grace is my commute being at 5:30 am and 4:00 pm. Have I have to be on the roads during “regular” commute, I think I’d be suicidal after 5 minutes of sharing the road with everyone who think they’re out on the glaciers of Iceland, trying to drive a sports cars with slick tires.

big john

It's bad enough when ti rains.

On a different note, 3 of us got out for a nice ride today. It warmed back up to the 60s and there was just a little headwind on the return trip. We ride past Vasquez rocks, a tourist attraction where movies are shot. My dad took me and my sisters there when we were kids.

genejockey 

I swear, I can see Jim Kirk trying to kill the Gorn from the top of those!

big john

They did the Flintstones movie there.

bampilot06

Thats great!