SwtBadger

You should probably tell someone at the RR about that.

WhyFi

So instead of blaming Rapha, we should be blaming the French language? Sounds about right to me.

Velo Vol 

For example

Velo Vol 

No one told me about the messages. Maybe Strava is worth $5 afterall.

Velo Vol 

Dear Velo Vol,

Impressive average speed today. You are awesome.

Love,

Strava

phrantic09

What do you take that has mouse genes?

Velo Vol 

Remicade

phrantic09

Oh. My dad was on that for a few years for Anklyosing Spondylitis until he had a reaction to it being treated in Hong Kong. Never knew it was mouse genes.

rjones28 

Nope.

Bah Humbug

The sport is more expensive than cycling. That checks out.

Bah Humbug

Should sail back over and give them the what-for. Do it in 46 years for poetic purposes.

rjones28 

Probably not.

genejockey 

It's a little thingie that shows up in the "Overview". I think it started in the last few months. Since all my riding since 1995 is on the same roads, and my rides are stitched together from different bits depending on where I decide to turn, even though I'd ridden every single segment of the ride dozens to hundreds of times since signing up with Strava in 2014, this is only the second time I'd stitched these precise segments in this precise order.

WhyFi

Sounds good, but I don't know if I can afford it - have you seen the prices on salopettes these days?

Bah Humbug

Deaths are a very lagging indicator. Don’t try to compare deaths and cases at the same time; this year has shown us that when “high infections, low deaths, is this as bad as we think it is?” turns into a lot of deaths a few weeks later.

genejockey 

Does a gilet have a place to put a couple bidons?

Bah Humbug

But that’s the point - we call then trousers and then they’re cheaper.

genejockey 

Nothing. Anything that originated from mouse genes has to be laboriously re-engineered to humanize it so you don't have an immune response. A lot of the monoclonal antibody drugs originated as mouse antibodies. We clone out the genes and then take the sticky bits that bind the target, and build them into a human antibody gene framework.

EDIT: Remicade is one of those mAb products that isn't human or humanized. I'm surprised there are so many chimerics on the market, especially for chronic diseases. You'd think HAMA would be a problem (Human Anti Mouse Antibodies)

genejockey 

During my brief flirtation with sailing 30 years ago, we called them "Foulies".

genejockey 

Yep. Again and again - "We're seeing a lot of new cases, but hospitalizations aren't rising. Maybe the virus has mutated to a less virulent form?"

2 weeks later: "Hospitalizations are really high, but deaths haven't risen. Perhaps the virus isn't as fatal as it was?"

2 weeks later still: "Deaths are rising rapidly. So, no. The virus is still just as bad."

Velo Vol 

Agree to disagree.

big john

What kind of pedals?

genejockey 

Observe Edit.

genejockey 

But to your original point, bats would be hell to make antibodies out of. Mice, at least, don't fly out when you open the cage to immunize them. And you can lift them by the tail and they can't bite you.

big john

That's cold. One of Jon Bon Jovi's brothers was a customer where I used to work and he had a 1969 Camaro Indy 500 pace car without the graphics. The thing was perfect but he would find some flaw and bring it in, cost no object and time no issue. The perfect customer and a nice guy. He found a scratch in one of the rear quarter windows so he said replace all the windows and weatherstripping. I don't know if he ever drove it anywhere.