Bike Forums

Bike Forums (https://www.bikeforums.net/forum.php)
-   Road Cycling (https://www.bikeforums.net/forumdisplay.php?f=41)
-   -   Addiction 2021.4 (https://www.bikeforums.net/showthread.php?t=1239811)

datlas 12-21-21 10:41 AM


Originally Posted by Velo Vol (Post 22347377)
Even if we don't have patient overflow, the personnel strain this puts on places that are already short-staffed is not great. They're having trouble finding anyone to work, even with crazy incentives.

Understood. There are two other hospitals nearby and both of them are closing (one on 12/31 and one on 1/31), so my local hospital may be overwhelmed. I think I am still on a stupid stand-by list to work the floors if they get desperate, my hope is it does not come to that and that our patients who are vaccinated (most of them) won't get very sick.

WhyFi 12-21-21 10:47 AM

Rolled out on a short ride and it started to rain. Decided to cut it short, got back a half hour later, wiped down the bike and it stopped raining. **** you, rain.

phrantic09 12-21-21 10:52 AM


Originally Posted by Velo Vol (Post 22347377)
Even if we don't have patient overflow, the personnel strain this puts on places that are already short-staffed is not great. They're having trouble finding anyone to work, even with crazy incentives.

There are some hospitals around here with 400 open nursing positions they canít fill.

phrantic09 12-21-21 10:52 AM


Originally Posted by genejockey (Post 22347335)
This is why I swap the night before a ride.

It was a game time decision, had originally planned on the trainer

genejockey 12-21-21 11:12 AM


Originally Posted by datlas (Post 22347346)
Prolly. But my hope is that those who are vaccinated will have very minor illnesses so the hospitals/healthcare system won't be overwhelmed.

Sigh.

From what I'm hearing, in places like Rhode Island, the system already IS overwhelmed, and that's BEFORE the full weight of Omichron falls. But again, the hospitalized are primarily unvaccinated. This has become an epidemic of the unvaccinated minority, and for the rest of us it's a continuing annoyance more than a constant threat.

BillyD 12-21-21 11:24 AM


Originally Posted by datlas (Post 22347192)
You mean it might be resistant to HCQ and Ivermectin??? :twitchy:

OMG Civilization doesn't have a chance if so. :eek:

MoAlpha 12-21-21 11:29 AM


Originally Posted by datlas (Post 22347192)
You mean it might be resistant to HCQ and Ivermectin??? :twitchy:

That would be pure speculation, now wouldn't it?

genejockey 12-21-21 11:31 AM


Originally Posted by ls01 (Post 22347372)
So simplified. Monoclonal, what works for one wont(?) Work for any other strain. Whereas a vaccine can be boosted for virus mutation.

Kinda/sorta.

Think of it this way: when you're vaccinated, or infected, your body generates a wide range of antibodies. It does this by having a large pool of B-cells that produce a wide, wide range of different antibody specificities. The cells that produce antibodies that bind to the new pathogen get turned on, not only to reproduce and expand their numbers, but also to undergo their own evolution, in which cells that produce new versions of the original antibodies that bind better are stimulated to reproduce and expand. This leads to your cells producing a whole bunch of antibodies that bind to different places on the virus, so that even if you encounter a new version of the virus that some antibodies don't bind to, there will still be ones that do, and the cells that produce those will expand. This is a POLYclonal response - MANY different antibodies, and also numerous different versions of the original antibodies that kinda/sorta bound, but whose binding has been enhanced by mutation and testing, mutation and testing, mutation and testing. This is why each successive round of immunization increases the efficacy - it stimulates further expansion, mutation and testing.

A monoclonal antibody is made by isolating individual antibody producing cells, finding the one 'best' antibody, decoding the genes to make it, and then using them to make kilograms of that ONE antibody. Hence MONOclonal.

BUT, in addition to the antibody producing cells, the whole immune system is primed to attack the virus and any cells infected with it, so that the infection gets snuffed out as quickly as possible. Each boost refines and broadens the response, so it's not just antibodies, it's also killer T-cells.

Sorry if this is longwinded, but it's why the vaccine, and boosting is so important - it gives the immune system a leg up, so that it's as strong against the virus as if you had been fighting the infection for a week or more already before it even sees the virus. And the immune cells that produce antiviral antibodies, or know how to kill virally infected cells produce 'memory cells' that hang around for years, so that if you ever see that pathogen again, your immune system says, "Oh, yeah! I've seen this! I need these cells to wake up and get to work!", rather than having to come up with a response from baseline again.

WhyFi 12-21-21 11:33 AM


Originally Posted by MoAlpha (Post 22347445)
That would be pure speculation, now wouldn't it?

I suspect that he's one of them liberal elites.

genejockey 12-21-21 11:35 AM


Originally Posted by phrantic09 (Post 22347396)
There are some hospitals around here with 400 open nursing positions they canít fill.

Gee, I can't imagine why. :notamused:

genejockey 12-21-21 11:35 AM


Originally Posted by MoAlpha (Post 22347445)
That would be pure speculation, now wouldn't it?

I'm sure they're every bit as effective against Omichron as they are against Alpha and Delta.

rjones28 12-21-21 11:40 AM


Originally Posted by Velo Vol (Post 22347344)
There's going to be a lot of breakthroughs the next few weeks.


ls01 12-21-21 11:46 AM


Originally Posted by genejockey (Post 22347294)
It's like you don't even know me...

What I HAVE been doing is, I took the Canyon off the trainer and put it in with the others so I can see how much space they take up, and amazingly it's still only a 7' x 7' x7' cube. But the Litespeed will be down to the bare frame next week anyhow while I clean all the bits. That reminds me I need to order the decals from Litespeed......

Done. Wonders of modern society. Now I just need the red Scotchbrite pads, and some acetone.

What I was trying to hint at is, once you ride that Ti beauty you won't need those other bikes.

datlas 12-21-21 11:49 AM


Originally Posted by genejockey (Post 22347448)
Kinda/sorta.

Think of it this way: when you're vaccinated, or infected, your body generates a wide range of antibodies. It does this by having a large pool of B-cells that produce a wide, wide range of different antibody specificities. The cells that produce antibodies that bind to the new pathogen get turned on, not only to reproduce and expand their numbers, but also to undergo their own evolution, in which cells that produce new versions of the original antibodies that bind better are stimulated to reproduce and expand. This leads to your cells producing a whole bunch of antibodies that bind to different places on the virus, so that even if you encounter a new version of the virus that some antibodies don't bind to, there will still be ones that do, and the cells that produce those will expand. This is a POLYclonal response - MANY different antibodies, and also numerous different versions of the original antibodies that kinda/sorta bound, but whose binding has been enhanced by mutation and testing, mutation and testing, mutation and testing. This is why each successive round of immunization increases the efficacy - it stimulates further expansion, mutation and testing.

A monoclonal antibody is made by isolating individual antibody producing cells, finding the one 'best' antibody, decoding the genes to make it, and then using them to make kilograms of that ONE antibody. Hence MONOclonal.

BUT, in addition to the antibody producing cells, the whole immune system is primed to attack the virus and any cells infected with it, so that the infection gets snuffed out as quickly as possible. Each boost refines and broadens the response, so it's not just antibodies, it's also killer T-cells.

Sorry if this is longwinded, but it's why the vaccine, and boosting is so important - it gives the immune system a leg up, so that it's as strong against the virus as if you had been fighting the infection for a week or more already before it even sees the virus. And the immune cells that produce antiviral antibodies, or know how to kill virally infected cells produce 'memory cells' that hang around for years, so that if you ever see that pathogen again, your immune system says, "Oh, yeah! I've seen this! I need these cells to wake up and get to work!", rather than having to come up with a response from baseline again.

I have one word to say. Just ONE word!

Epitope.

genejockey 12-21-21 11:52 AM


Originally Posted by ls01 (Post 22347465)
What I was trying to hint at is, once you ride that Ti beauty you won't need those other bikes.

Need? What's this "Need" nonsense? :rolleyes:

To be fair, I have been thinking about selling the Lotus Classique. It's a nice bike, but as a Sport Tourer, it doesn't really fit so well into the stable, and unlike the others I don't find myself wanting to ride it. There's not a thing wrong with it - it was probably in the best condition when acquired, and it's in even better shape now - but it just doesn't make me want to ride it. It just needs a replacement for one of the black wraps on the downtube, and it will be done.

genejockey 12-21-21 11:55 AM


Originally Posted by datlas (Post 22347471)
I have one word to say. Just ONE word!

Epitope.

And here I was trying to avoid jargon.

datlas 12-21-21 11:57 AM


Originally Posted by genejockey (Post 22347475)
And here I was trying to avoid jargon.

You know how much I love it when you talk science.

ls01 12-21-21 11:57 AM


Originally Posted by BillyD (Post 22347441)
OMG Civilization doesn't have a chance if so. :eek:

we lost civilization a long time ago.

BillyD 12-21-21 12:29 PM


Originally Posted by ls01 (Post 22347465)
What I was trying to hint at is, once you ride that Ti beauty you won't need those other bikes.

Well ... Ti is fly ... but steel is real. But, yeah, the aluminum ones and carbon ones can now go in the garbage.

genejockey 12-21-21 12:35 PM


Originally Posted by BillyD (Post 22347499)
Well ... Ti is fly ... but steel is real. But, yeah, the aluminum ones and carbon ones can now go in the garbage.

So if steel is "gas pipe" and aluminum is "beer can" and carbon fiber is "plastic", what's the slang for Ti?

MoAlpha 12-21-21 12:37 PM


Originally Posted by genejockey (Post 22347453)
I'm sure they're every bit as effective against Omichron as they are against Alpha and Delta.

Concentration is important.

MoAlpha 12-21-21 12:41 PM


Originally Posted by genejockey (Post 22347507)
So if steel is "gas pipe" and aluminum is "beer can" and carbon fiber is "plastic", what's the slang for Ti?

Healthcare provider vanity tubing (HPVT).

genejockey 12-21-21 12:44 PM


Originally Posted by MoAlpha (Post 22347515)
Healthcare provider vanity tubing (HPVT).

Was this purchase a mistake? Am I gonna be mistaken for a dentist? I mean, I work in healthcare, but at the other end of the drug development pipeline. My job is tossing things into one end of the pipeline.

Mojo31 12-21-21 12:44 PM


Originally Posted by genejockey (Post 22347507)
So if steel is "gas pipe" and aluminum is "beer can" and carbon fiber is "plastic", what's the slang for Ti?

Explosive.

genejockey 12-21-21 12:50 PM


Originally Posted by Mojo31 (Post 22347521)
Explosive.

That's Magnesium.


All times are GMT -6. The time now is 03:55 PM.


Copyright © 2023 MH Sub I, LLC dba Internet Brands. All rights reserved. Use of this site indicates your consent to the Terms of Use.